Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
USERS' SCORE
Moderately Good
Based on 114 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
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8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Read More
Most Useful Reviews
9
Liver detox support
119 people found this helpful
Glutathione is an exceptional hepatoprotector that safeguards the liver and the entire body from toxins and viruses. I recommend it particularly for those with alcohol or nicotine dependencies. It plays a vital role in liver detoxification and acts as a precursor to glutathione peroxidase, the main free radical scavenger enzyme. Its sulphur-containing groups effectively detoxify the body, lend antioxidant benefits, and can help delay the ageing process.
Read More
8
Quality improvement observed
72 people found this helpful
I have noticed excellent quality in this product for over three weeks. My face looks clearer due to its anti-free radicals and antioxidant properties, effectively detoxifying the liver. Overall, I've felt a general improvement in my well-being.
Read More
9
Energy boost experienced
70 people found this helpful
An excellent drug! Having taken it on a friend's recommendation for two weeks, I'm already experiencing tangible changes in my body. Taken on an empty stomach in the morning, I felt a surge of strength and energy by the second day. Besides, my skin feels as soft as a baby's. Notably, there are significant benefits for my liver too, which is crucial during these times.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.6
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
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9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
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8
We explored the effects of ACT001 on metabolic associated fatty liver disease (MAFLD) in a study involving mice. By analyzing transcriptomic and metabolomic data, we measured liver enzymes and lipid levels, finding that ACT001 significantly reduced both.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
Read More
8
We examined how Mogroside V (MV), a natural compound, may protect the liver from damage caused by acetaminophen (APAP). In our study, mice were split into three groups: a control group, an APAP-only group, and an APAP group that also received MV.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 114 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver detox support
119 people found this helpful
Glutathione is an exceptional hepatoprotector that safeguards the liver and the entire body from toxins and viruses. I recommend it particularly for those with alcohol or nicotine dependencies. It plays a vital role in liver detoxification and acts as a precursor to glutathione peroxidase, the main free radical scavenger enzyme. Its sulphur-containing groups effectively detoxify the body, lend antioxidant benefits, and can help delay the ageing process.
Read More
8
Quality improvement observed
72 people found this helpful
I have noticed excellent quality in this product for over three weeks. My face looks clearer due to its anti-free radicals and antioxidant properties, effectively detoxifying the liver. Overall, I've felt a general improvement in my well-being.
Read More
9
Energy boost experienced
70 people found this helpful
An excellent drug! Having taken it on a friend's recommendation for two weeks, I'm already experiencing tangible changes in my body. Taken on an empty stomach in the morning, I felt a surge of strength and energy by the second day. Besides, my skin feels as soft as a baby's. Notably, there are significant benefits for my liver too, which is crucial during these times.
Read More
9
Enhances liver detoxification
48 people found this helpful
After a month of glutathione, I noticed that my morning fatigue disappeared. It supports liver function and helps detoxify after evening drinking. At my age, feeling youthful is essential, and glutathione effectively combats ageing while promoting health and beauty.
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9
Recommended for liver
40 people found this helpful
I have used Glutathione for a long time, and it helps me feel good and regenerate my liver. When my cat had liver issues, I gave it this herb, and in just two weeks, my cat was healthy again. I highly recommend liver cleansing for everyone to help recover and feel healthy and happy.
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Frequently Asked Questions
9
Energy boost experienced
70 people found this helpful
An excellent drug! Having taken it on a friend's recommendation for two weeks, I'm already experiencing tangible changes in my body. Taken on an empty stomach in the morning, I felt a surge of strength and energy by the second day. Besides, my skin feels as soft as a baby's. Notably, there are significant benefits for my liver too, which is crucial during these times.
9
Enhances liver detoxification
48 people found this helpful
After a month of glutathione, I noticed that my morning fatigue disappeared. It supports liver function and helps detoxify after evening drinking. At my age, feeling youthful is essential, and glutathione effectively combats ageing while promoting health and beauty.
10
Remarkable liver recovery
7 people found this helpful
I started taking this alongside silymarin, NAC, lecithin, hepadif, and turmeric oil for liver support. In just four days, my AST and ALT levels returned to normal, dropping even lower within a week. I've also noticed the disappearance of deep pimples under my jaw. This is incredible, and I attribute it mainly to glutathione, which I used for the first time.
8
Quality improvement observed
72 people found this helpful
I have noticed excellent quality in this product for over three weeks. My face looks clearer due to its anti-free radicals and antioxidant properties, effectively detoxifying the liver. Overall, I've felt a general improvement in my well-being.
9
Boosted energy levels
6 people found this helpful
I'm nearing the end of my second can, and I can affirm that this product works. My general condition has improved; daytime drowsiness and lethargy have vanished. I feel energised, and my tests reflect good liver functions. I plan to take a month off before repeating the course, which pairs well with alpha-lipoic acid.
7.5
Reduced fatigue
2 people found this helpful
A fantastic skin saver! It cleared my acne, softened my skin, and surprisingly reduced my fatigue, likely because glutathione repairs the liver, leaving me less tired. My dark circles also improved. I take it with vitamin C for added benefit! If this review helps you, a thumbs up would be appreciated!
9
Refreshed mornings
2 people found this helpful
Accelerate liver detoxification! I’ve taken this product daily for a year; I rarely experience hangovers and wake up refreshed. On days I feel less energetic, I take vitamin C as well. I am truly grateful for this find.
8
Vitality enhancement noted
5 people found this helpful
This supplement well supports detoxification and liver health, boosting my energy and optimism. I've tried several brands, but this one, with added alpha-lipoic acid and silymarin, is particularly effective. I’d recommend taking one capsule daily for a course of 1-2 months, followed by a break.
9
Liver support acknowledged
6 people found this helpful
Since starting the course six months ago, my son has undergone tests every three months. We use glutathione to assist his liver, and it has proven effective. He takes the medication precisely as prescribed by his doctor, ensuring that all dosages align with professional recommendations.
8
We explored the effects of ACT001 on metabolic associated fatty liver disease (MAFLD) in a study involving mice. By analyzing transcriptomic and metabolomic data, we measured liver enzymes and lipid levels, finding that ACT001 significantly reduced both.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
8
We examined how Mogroside V (MV), a natural compound, may protect the liver from damage caused by acetaminophen (APAP). In our study, mice were split into three groups: a control group, an APAP-only group, and an APAP group that also received MV.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
8
We explored the role of silymarin, a compound from milk thistle, as an antioxidant treatment for chronic liver diseases like hepatitis and cirrhosis. Through a thorough review of clinical studies, we found that silymarin shows promise for protecting the liver and may help improve liver function in patients with these conditions.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
7
We explored the effects of silymarin, a natural compound derived from milk thistle, on various liver diseases like cirrhosis and fatty liver. Through extensive clinical trials, we observed that silymarin has impressive antioxidant and hepatoprotective properties, which can help prevent further liver damage and reduce symptoms in patients. This herbal remedy shows promise in improving liver function and has a good safety record with mild side effects. Overall, silymarin stands out as a beneficial option in managing liver health.
References
- Liu J, Zhou Y, Li Y, Chen Z, Jiao X, et al. Integrative transcriptomic and metabolomic analysis explores the mechanisms by which ACT001 treats MAFLD in mice. Sci Rep. 2025;15:12494. doi:10.1038/s41598-025-97312-9
- Shi JL, Sun T, Li Q, Li CM, Jin JF, et al. Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice. World J Hepatol. 2025;17:104520. doi:10.4254/wjh.v17.i3.104520
- Yu S, Wang Y, Shi Y, Yu S, Zhao B, et al. Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway. Bioeng Transl Med. 2025;10:e10735. doi:10.1002/btm2.10735
- Gao S, Wang X, Xu Q, Li R, Yao L, et al. Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice. J Ethnopharmacol. 2025;345:119571. doi:10.1016/j.jep.2025.119571
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. doi:10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. doi:10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. doi:10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. doi:10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. doi:10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. doi:10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. doi:10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. doi:10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. doi:10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. doi:10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. doi:10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. doi:10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. doi:10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. doi:10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
- Zhao Y, Guo M, Pei T, Shang C, Chen Y, et al. α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte. Adv Sci (Weinh). 2025. doi:10.1002/advs.202413255
